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Issue 31, 2014
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A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines via dual C(sp3)–H/C(sp2)–H functionalizations

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Abstract

A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines has been developed through dual C(sp3)–H/C(sp2)–H functionalizations. The synthetic method has the advantages of high yields, good compatibility of functional groups and mild reaction conditions, although very unreactive alkanes were involved in the reaction. A plausible mechanism through both copper-catalyzed and DTBP mediated pathways has also been proposed.

Graphical abstract: A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines via dual C(sp3)–H/C(sp2)–H functionalizations

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Publication details

The article was received on 17 Apr 2014, accepted on 20 Jun 2014 and first published on 04 Jul 2014


Article type: Communication
DOI: 10.1039/C4OB01256A
Citation: Org. Biomol. Chem., 2014,12, 5839-5842
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    A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines via dual C(sp3)–H/C(sp2)–H functionalizations

    Z. Zhu, T. Wang, P. Bai and Z. Huang, Org. Biomol. Chem., 2014, 12, 5839
    DOI: 10.1039/C4OB01256A

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