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Issue 38, 2014
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Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

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Abstract

Total synthesis of cryptocin, a fungus metabolite, was achieved based on the biosynthetic hypothesis. A variety of derivatives of cryptocin, equisetin and fusarisetin A were prepared, wherein the racemization of C-3 and diastereoselectivity of C-5 were investigated. We further examined their inhibitory effects on breast cancer cell survival and metastasis, and summarized the structure–activity relationship.

Graphical abstract: Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

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The article was received on 04 Jun 2014, accepted on 04 Aug 2014 and first published on 04 Aug 2014


Article type: Paper
DOI: 10.1039/C4OB01149J
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Citation: Org. Biomol. Chem., 2014,12, 7591-7597
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    Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A

    L. Kong, M. Rao, J. Ou, J. Yin, W. Lu, M. Liu, X. Pang and S. Gao, Org. Biomol. Chem., 2014, 12, 7591
    DOI: 10.1039/C4OB01149J

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