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Issue 33, 2014
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Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

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Abstract

The light-driven artificial enzymes were constructed to realize unnatural reactions concerning bio-significant molecules. In this manuscript, the guanosine triphosphate (GTP)-selective oxidation is reported using the network polymers composed of polyhedral oligomeric silsesquioxane (POSS). We synthesized the water-soluble POSS network polymer containing the naphthyridine ligands to capture GTP inside the networks and the ruthenium complexes to oxidize the captured GTP under light irradiation. Initially, the binding affinities of the guanosine nucleosides to the naphthyridine ligand inside the POSS network polymer were evaluated from the emission quenching experiments. Accordingly, it was observed that the naphthyridine ligand can form the stable complex only with GTP (Ka = 5.5 × 106 M−1). These results indicate that only GTP can be captured by the network polymer. Next, the photo-catalytic activity of the ruthenium complex-modified POSS network polymer was investigated. Finally, it was revealed that the network polymer can decompose GTP efficiently under light irradiation. This is the first example, to the best of our knowledge, to offer not only the GTP-selective host polymers but also the light-driven artificial enzyme for GTP oxidation.

Graphical abstract: Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

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Publication details

The article was received on 30 May 2014, accepted on 25 Jun 2014 and first published on 15 Jul 2014


Article type: Paper
DOI: 10.1039/C4OB01115E
Citation: Org. Biomol. Chem., 2014,12, 6500-6506
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    Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

    J. Jeon, K. Tanaka and Y. Chujo, Org. Biomol. Chem., 2014, 12, 6500
    DOI: 10.1039/C4OB01115E

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