Issue 33, 2014

Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

Abstract

The light-driven artificial enzymes were constructed to realize unnatural reactions concerning bio-significant molecules. In this manuscript, the guanosine triphosphate (GTP)-selective oxidation is reported using the network polymers composed of polyhedral oligomeric silsesquioxane (POSS). We synthesized the water-soluble POSS network polymer containing the naphthyridine ligands to capture GTP inside the networks and the ruthenium complexes to oxidize the captured GTP under light irradiation. Initially, the binding affinities of the guanosine nucleosides to the naphthyridine ligand inside the POSS network polymer were evaluated from the emission quenching experiments. Accordingly, it was observed that the naphthyridine ligand can form the stable complex only with GTP (Ka = 5.5 × 106 M−1). These results indicate that only GTP can be captured by the network polymer. Next, the photo-catalytic activity of the ruthenium complex-modified POSS network polymer was investigated. Finally, it was revealed that the network polymer can decompose GTP efficiently under light irradiation. This is the first example, to the best of our knowledge, to offer not only the GTP-selective host polymers but also the light-driven artificial enzyme for GTP oxidation.

Graphical abstract: Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

Supplementary files

Article information

Article type
Paper
Submitted
30 May 2014
Accepted
25 Jun 2014
First published
15 Jul 2014

Org. Biomol. Chem., 2014,12, 6500-6506

Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

J. Jeon, K. Tanaka and Y. Chujo, Org. Biomol. Chem., 2014, 12, 6500 DOI: 10.1039/C4OB01115E

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