Issue 29, 2014
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides: synthesis of phenanthridinones†

Yuan Yang,a   Hui Huang,a   Lijun Wua  and  Yun liang*ab  

* Corresponding authors

a National & Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, Hunan 410081, China
E-mail: yliang@hunnu.edu.cn
Fax: +86(0731)88872533

b Beijing National Laboratory for Molecular Sciences, Beijing, China

Abstract

A novel and efficient procedure for the synthesis of N-substituted phenanthridinones via palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides has been developed. This methodology constructs two new C–C bonds via an arylation/annulation process, and provides the desired products in good yields.

Graphical abstract: Palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides: synthesis of phenanthridinones

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Article information

DOI
https://doi.org/10.1039/C4OB00997E
Article type
Communication
Submitted
14 May 2014
Accepted
03 Jun 2014
First published
03 Jun 2014

Org. Biomol. Chem., 2014,12, 5351-5355

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Palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides: synthesis of phenanthridinones

Y. Yang, H. Huang, L. Wu and Y. liang, Org. Biomol. Chem., 2014, 12, 5351 DOI: 10.1039/C4OB00997E

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