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Issue 30, 2014
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Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells

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Abstract

Hydrogen sulfide (H2S) has been regarded as the third gaseous transmitter. Based on the mechanism of chemoselective azido reduction and self-immolation, five fluorescence resonance energy transfer (FRET) probes for the detection of H2S were designed and synthesized. The effect of functional substitution of the self-immolative moiety on azido reduction and quinone-methide rearrangement were investigated. Their fluorescence responses and chemoselectivity for H2S detection were evaluated in solutions and in cells. This strategy may provide a general route for designing H2S probes with many commercially available FRET pairs.

Graphical abstract: Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells

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Publication details

The article was received on 05 May 2014, accepted on 04 Jun 2014 and first published on 04 Jun 2014


Article type: Paper
DOI: 10.1039/C4OB00923A
Citation: Org. Biomol. Chem., 2014,12, 5629-5633
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    Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells

    B. Chen, P. Wang, Q. Jin and X. Tang, Org. Biomol. Chem., 2014, 12, 5629
    DOI: 10.1039/C4OB00923A

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