Jump to main content
Jump to site search

Issue 25, 2014
Previous Article Next Article

Brønsted acid mediated nitrogenation of propargylic alcohols: an efficient approach to alkenyl nitriles

Author affiliations

Abstract

A novel and efficient approach to alkenyl nitriles from readily available propargylic alcohols has been developed. This nitrogenation reaction is transition-metal-free and could be conducted under air at ambient temperature, which makes this protocol promising and practical. Moreover, NH4Br is disclosed as an efficient additive to promote the stereoselectivity of this reaction.

Graphical abstract: Brønsted acid mediated nitrogenation of propargylic alcohols: an efficient approach to alkenyl nitriles

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 May 2014, accepted on 02 May 2014 and first published on 02 May 2014


Article type: Communication
DOI: 10.1039/C4OB00888J
Citation: Org. Biomol. Chem., 2014,12, 4324-4328
  •   Request permissions

    Brønsted acid mediated nitrogenation of propargylic alcohols: an efficient approach to alkenyl nitriles

    X. Huang and N. Jiao, Org. Biomol. Chem., 2014, 12, 4324
    DOI: 10.1039/C4OB00888J

Search articles by author