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Issue 38, 2014
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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

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Abstract

Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors.

Graphical abstract: Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

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Supplementary files

Publication details

The article was received on 26 Apr 2014, accepted on 12 Aug 2014 and first published on 13 Aug 2014


Article type: Communication
DOI: 10.1039/C4OB00860J
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 7498-7502
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    Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

    B. He, J. Hu, X. Zhang and H. Lin, Org. Biomol. Chem., 2014, 12, 7498
    DOI: 10.1039/C4OB00860J

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