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Issue 30, 2014
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Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles

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Abstract

An iron-catalyzed aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed, which is a rare example where a cosolvent is used to improve the reaction yield along with Fenton's reagent and thus provides an economic and green method for the synthesis of a variety of difluoromethylated oxindoles. Preliminary mechanistic investigations indicate a radical addition path.

Graphical abstract: Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles

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Publication details

The article was received on 10 Apr 2014, accepted on 30 May 2014 and first published on 03 Jun 2014


Article type: Communication
DOI: 10.1039/C4OB00758A
Citation: Org. Biomol. Chem., 2014,12, 5582-5585
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    Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles

    J. Wang, X. Zhang, Y. Bao, Y. Xu, X. Cheng and X. Wang, Org. Biomol. Chem., 2014, 12, 5582
    DOI: 10.1039/C4OB00758A

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