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Issue 23, 2014
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Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes

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Abstract

We describe a practical, large-scale synthesis of the “fairy-ring” plant-growth regulator 2-azahypoxanthine (AHX), and its biologically active hydroxyl metabolite (AOH) and riboside derivative (AHXr). AHXr, a biosynthetic intermediate, was synthesized from inosine via a biomimetic route. Biotinylated derivatives of AHX and AHXr were also synthesized as probes for mechanistic studies.

Graphical abstract: Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes

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Publication details

The article was received on 03 Apr 2014, accepted on 14 Apr 2014 and first published on 14 Apr 2014


Article type: Communication
DOI: 10.1039/C4OB00705K
Citation: Org. Biomol. Chem., 2014,12, 3813-3815
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    Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes

    K. Ikeuchi, R. Fujii, S. Sugiyama, T. Asakawa, M. Inai, Y. Hamashima, J. Choi, T. Suzuki, H. Kawagishi and T. Kan, Org. Biomol. Chem., 2014, 12, 3813
    DOI: 10.1039/C4OB00705K

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