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Issue 27, 2014
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Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

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Abstract

A convenient one-pot reaction was conducted by mixing bromoacetophenone, a functionalized α,β-unsaturated ketone and potassium hydroxide in tetrahydrofuran at room temperature, ammonium acetate was added and heated to reflux, resulting in four chemical bonds forming from easily accessible substrates. This process provides a flexible and rapid synthetic route for the construction of polysubstituted benzofuro[2,3-c]pyridines in moderate to good yields.

Graphical abstract: Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

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Publication details

The article was received on 30 Mar 2014, accepted on 16 Apr 2014 and first published on 16 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00670D
Citation: Org. Biomol. Chem., 2014,12, 4885-4889
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    Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

    J. Hu, Z. Deng, X. Zhang, F. Zhang and H. Zheng, Org. Biomol. Chem., 2014, 12, 4885
    DOI: 10.1039/C4OB00670D

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