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Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPARγ modulator

Jingjing Shi,a   Guanguan Zhao,a   Xiaowei Wang,a   H. Eric Xu*ab and   Wei Yi*a  
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a
VARI/SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China
E-mail: yiwei.simm@simm.ac.cn, eric.xu@simm.ac.cn;
Fax: +86-21-20231000-1709 ;
Tel: +86-21-20231000-1715
b
Laboratory of Structural Sciences, Program on Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, USA
Org. Biomol. Chem., 2014,12, 6831-6836

DOI: 10.1039/C4OB00637B
Received 26 Mar 2014, Accepted 09 May 2014
First published online 09 May 2014
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