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Issue 28, 2014
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Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

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Abstract

Applying psoralen interstrand crosslinks for the photoactivation of nucleic acids is a new concept. To find chromophores that can efficiently stimulate crosslink repair we screened several pyrenes and appended them to peptide nucleic acids for their site-selective addressing. Even though pyrenes conjugated to uracil revealed desirable spectroscopic properties they were not effective in crosslink reversal. In contrast, bare pyrenes are well suitable for crosslink repair with 350 nm light showing an uncaging efficiency similar to classical photocaging groups.

Graphical abstract: Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

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Publication details

The article was received on 20 Mar 2014, accepted on 22 May 2014 and first published on 23 May 2014


Article type: Paper
DOI: 10.1039/C4OB00603H
Citation: Org. Biomol. Chem., 2014,12, 5260-5266
  • Open access: Creative Commons BY-NC license
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    Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

    J. M. Stadler and T. Stafforst, Org. Biomol. Chem., 2014, 12, 5260
    DOI: 10.1039/C4OB00603H

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