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Issue 21, 2014
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Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

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Abstract

In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action.

Graphical abstract: Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

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Publication details

The article was received on 19 Mar 2014, accepted on 23 Mar 2014 and first published on 25 Mar 2014


Article type: Paper
DOI: 10.1039/C4OB00598H
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 3470-3477
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    Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

    R. F. S. Canto, F. A. R. Barbosa, V. Nascimento, A. S. de Oliveira, I. M. C. Brighente and A. L. Braga, Org. Biomol. Chem., 2014, 12, 3470
    DOI: 10.1039/C4OB00598H

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