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Issue 30, 2014
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Strategies for desymmetrising trehalose to synthesise trehalose glycolipids

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Abstract

The desymmetrisation and regioselective protection of trehalose are major challenges in the chemical synthesis of biologically essential trehalose glycolipids. We reviewed the literature on desymmetrising trehalose to synthesise trehalose glycolipids and highlighted an efficient regioselective 6-O-phosphorylation method that can be applied to synthesise asymmetric trehalose glycolipids.

Graphical abstract: Strategies for desymmetrising trehalose to synthesise trehalose glycolipids

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Publication details

The article was received on 19 Mar 2014, accepted on 05 Jun 2014 and first published on 05 Jun 2014


Article type: Perspective
DOI: 10.1039/C4OB00587B
Citation: Org. Biomol. Chem., 2014,12, 5558-5562
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    Strategies for desymmetrising trehalose to synthesise trehalose glycolipids

    C. Wu and C. Wang, Org. Biomol. Chem., 2014, 12, 5558
    DOI: 10.1039/C4OB00587B

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