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Issue 27, 2014
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A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

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Abstract

A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4]arene cavity, has been synthesized. The complexation behaviour of receptor L was studied by means of fluorescence spectra and 1H NMR titration experiments in the presence of K+ ions and a variety of other anions. The results suggested that receptor L can complex efficiently via the urea cavity or the crown ether moiety, and a positive/negative allosteric effect operating in receptor L was observed.

Graphical abstract: A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

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Publication details

The article was received on 12 Mar 2014, accepted on 09 May 2014 and first published on 12 May 2014


Article type: Paper
DOI: 10.1039/C4OB00551A
Citation: Org. Biomol. Chem., 2014,12, 4917-4923
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    A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

    H. Tomiyasu, C. Jin, X. Ni, X. Zeng, C. Redshaw and T. Yamato, Org. Biomol. Chem., 2014, 12, 4917
    DOI: 10.1039/C4OB00551A

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