Issue 27, 2014

A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

Abstract

A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4]arene cavity, has been synthesized. The complexation behaviour of receptor L was studied by means of fluorescence spectra and 1H NMR titration experiments in the presence of K+ ions and a variety of other anions. The results suggested that receptor L can complex efficiently via the urea cavity or the crown ether moiety, and a positive/negative allosteric effect operating in receptor L was observed.

Graphical abstract: A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

Supplementary files

Article information

Article type
Paper
Submitted
12 Mar 2014
Accepted
09 May 2014
First published
12 May 2014

Org. Biomol. Chem., 2014,12, 4917-4923

Author version available

A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

H. Tomiyasu, C. Jin, X. Ni, X. Zeng, C. Redshaw and T. Yamato, Org. Biomol. Chem., 2014, 12, 4917 DOI: 10.1039/C4OB00551A

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