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Issue 27, 2014
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A mitochondria-targeted turn-on fluorescent probe based on a rhodol platform for the detection of copper(I)

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Abstract

A new spirocyclized rhodol-based fluorescent probe has been developed for detecting mitochondrial Cu+. Alkylation of the hydroxy group of a xanthene moiety with a tris(2-pyridylmethyl)amine-based ligand induced the formation of a non-fluorescent spirocyclic structure. The reaction with Cu+ in the presence of submillimolar concentrations of glutathione at physiological pH resulted in the elimination of the ligand together with an increase in the fluorescence of the rhodol fluorophore. This probe was used to visualize mitochondrial Cu+ in copper supplemented cells.

Graphical abstract: A mitochondria-targeted turn-on fluorescent probe based on a rhodol platform for the detection of copper(i)

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Publication details

The article was received on 10 Mar 2014, accepted on 12 May 2014, published on 12 May 2014 and first published online on 12 May 2014


Article type: Paper
DOI: 10.1039/C4OB00527A
Citation: Org. Biomol. Chem., 2014,12, 4999-5005
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    A mitochondria-targeted turn-on fluorescent probe based on a rhodol platform for the detection of copper(I)

    M. Taki, K. Akaoka, K. Mitsui and Y. Yamamoto, Org. Biomol. Chem., 2014, 12, 4999
    DOI: 10.1039/C4OB00527A

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