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Issue 23, 2014
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Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries

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Abstract

An example of the subtle interplay between the intended templation and a very fast reequilibration of a dynamic combinatorial library of imines that occurs upon a solvent change is reported. Such seemingly “irrelevant” details of the procedure like imine dissolution time prior to reduction may dictate the outcome of the whole reaction.

Graphical abstract: Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries

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Publication details

The article was received on 06 Mar 2014, accepted on 08 Apr 2014 and first published on 08 May 2014


Article type: Communication
DOI: 10.1039/C4OB00507D
Citation: Org. Biomol. Chem., 2014,12, 3827-3830
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    Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries

    K. Ziach, A. Kulesza and J. Jurczak, Org. Biomol. Chem., 2014, 12, 3827
    DOI: 10.1039/C4OB00507D

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