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Issue 26, 2014
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Incrementally increasing the length of a peptide backbone: effect on macrocyclisation efficiency

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Abstract

Three novel analogues of the cyclic pentapeptide sansalvamide A have been synthesised in high yield. A leucine residue in the lead compound is replaced with either a glycine, β-alanine or GABA residue, and the corresponding linear precursor peptides are found to cyclise with dramatically improved efficiency. This correlates with an increase in the effective molarity (EM) of the cyclisation reactions.

Graphical abstract: Incrementally increasing the length of a peptide backbone: effect on macrocyclisation efficiency

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Publication details

The article was received on 05 Mar 2014, accepted on 27 May 2014 and first published on 28 May 2014


Article type: Communication
DOI: 10.1039/C4OB00492B
Citation: Org. Biomol. Chem., 2014,12, 4598-4601
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    Incrementally increasing the length of a peptide backbone: effect on macrocyclisation efficiency

    Md. I. Ahmed, J. B. Harper and L. Hunter, Org. Biomol. Chem., 2014, 12, 4598
    DOI: 10.1039/C4OB00492B

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