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Issue 22, 2014
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The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic FexOy particles

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Abstract

Pyrrolidinyl PNA was immobilized on FexOy magnetic particles and was able to capture and thereby discriminate single base alterations in DNA counterstrands better than DNA. The selectivities of matched vs. mismatched oligonucleotides measured by the absorption differences were up to 10–12 which are remarkable values for linear probes.

Graphical abstract: The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic FexOy particles

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Publication details

The article was received on 04 Mar 2014, accepted on 08 Apr 2014 and first published on 08 Apr 2014


Article type: Communication
DOI: 10.1039/C4OB00487F
Citation: Org. Biomol. Chem., 2014,12, 3586-3589
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    The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic FexOy particles

    C. Stubinitzky, T. Vilaivan and H. Wagenknecht, Org. Biomol. Chem., 2014, 12, 3586
    DOI: 10.1039/C4OB00487F

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