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Issue 22, 2014
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Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

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Abstract

The use of alternative solvents in the iridium-catalysed hydrogen isotope exchange reaction with developing phosphine/NHC Ir(I) complexes has identified reaction media which are more widely applicable and industrially acceptable than the commonly employed chlorinated solvent, dichloromethane. Deuterium incorporation into a variety of substrates has proceeded to deliver high levels of labelling (and regioselectivity) in the presence of low catalyst loadings and over short reaction times. The preparative outputs have been complemented by DFT studies to explore ligand orientation, as well as solvent and substrate binding energies within the catalyst system.

Graphical abstract: Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

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Publication details

The article was received on 28 Feb 2014, accepted on 09 Apr 2014 and first published on 10 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00465E
Citation: Org. Biomol. Chem., 2014,12, 3598-3603
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    Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

    A. R. Cochrane, C. Idziak, W. J. Kerr, B. Mondal, L. C. Paterson, T. Tuttle, S. Andersson and G. N. Nilsson, Org. Biomol. Chem., 2014, 12, 3598
    DOI: 10.1039/C4OB00465E

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