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Issue 21, 2014
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Allosteric control of a DNA-hydrolyzing deoxyribozyme with short oligonucleotides and its application in DNA logic gates

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Abstract

Allosteric control of deoxyribozymes is useful for a broad range of practical applications, such as nucleic acid sensing and DNA-computing. We found that the catalytic activity of a DNA-hydrolyzing deoxyribozyme could be allosterically regulated by adding short oligonucleotides. We used this technique to construct deoxyribozyme-based logic gates.

Graphical abstract: Allosteric control of a DNA-hydrolyzing deoxyribozyme with short oligonucleotides and its application in DNA logic gates

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Publication details

The article was received on 27 Feb 2014, accepted on 24 Mar 2014 and first published on 17 Apr 2014


Article type: Communication
DOI: 10.1039/C4OB00451E
Citation: Org. Biomol. Chem., 2014,12, 3344-3348
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    Allosteric control of a DNA-hydrolyzing deoxyribozyme with short oligonucleotides and its application in DNA logic gates

    K. Furukawa and N. Minakawa, Org. Biomol. Chem., 2014, 12, 3344
    DOI: 10.1039/C4OB00451E

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