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Issue 25, 2014
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“One-pot” access to dihydrofurans via tandem oxidative difunctionalization and ring contraction of aminopyrans

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Abstract

An operationally simple and efficient protocol for the construction of dihydrofuran derivatives has been accomplished via a sequential addition of N-chlorosuccinimide and a base to 2-amino-4H-pyran derivatives in alcohol medium. The one-pot protocol proceeding via tandem oxidative difunctionalization and ring contraction provides an entirely new strategy for the construction of the dihydrofuran skeleton.

Graphical abstract: “One-pot” access to dihydrofurans via tandem oxidative difunctionalization and ring contraction of aminopyrans

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Publication details

The article was received on 12 Feb 2014, accepted on 09 Apr 2014 and first published on 09 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00324A
Citation: Org. Biomol. Chem., 2014,12, 4412-4420
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    “One-pot” access to dihydrofurans via tandem oxidative difunctionalization and ring contraction of aminopyrans

    S. R. Mandha, M. Alla and J. B. Nanubolu, Org. Biomol. Chem., 2014, 12, 4412
    DOI: 10.1039/C4OB00324A

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