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Issue 17, 2014
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Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint

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Abstract

αβα-Tripeptide that contains a cyclic β-amino acid with an eight-membered ring, a cis-2-aminocyclooct-5-enecarboxylic acid (cis-ACOE) or a cis-2-aminocyclooctanecarboxylic acid (cis-ACOC) displayed an 11/9-helical turn in the crystal state. The related α/β-peptide oligomers were shown to adopt 11/9-helical conformations in solution.

Graphical abstract: Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint

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Publication details

The article was received on 05 Feb 2014, accepted on 04 Mar 2014 and first published on 04 Mar 2014


Article type: Communication
DOI: 10.1039/C4OB00266K
Citation: Org. Biomol. Chem., 2014,12, 2641-2644
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    Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint

    W. Lee, S. Kwon, P. Kang, I. A. Guzei and S. H. Choi, Org. Biomol. Chem., 2014, 12, 2641
    DOI: 10.1039/C4OB00266K

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