Issue 19, 2014

N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

Abstract

Two new NHC adducts of cyclopalladated ferrocenylpyrazine complexes 1–2 have been prepared and characterized. An efficient NHC-modulated Pd/Cu cocatalyzed three-component coupling reaction for the synthesis of 2,6-diarylquinolines from aminobenzyl alcohols, aryl ketones, and arylboronic acids in air is described. The reaction involves oxidation, cyclization and Suzuki reactions. The luminescence of the resulting arylquinolines 3–30 was also investigated.

Graphical abstract: N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2014
Accepted
11 Mar 2014
First published
12 Mar 2014

Org. Biomol. Chem., 2014,12, 3114-3122

Author version available

N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

C. Xu, H. Li, X. Yuan, Z. Xiao, Z. Wang, W. Fu, B. Ji, X. Hao and M. Song, Org. Biomol. Chem., 2014, 12, 3114 DOI: 10.1039/C4OB00231H

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