Jump to main content
Jump to site search

Issue 22, 2014
Previous Article Next Article

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

Author affiliations

Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.

Graphical abstract: Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 28 Jan 2014, accepted on 04 Apr 2014 and first published on 04 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00220B
Citation: Org. Biomol. Chem., 2014,12, 3744-3754
  • Open access: Creative Commons BY license
  •   Request permissions

    Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

    C. Percivalle, C. Sissi, M. L. Greco, C. Musetti, A. Mariani, A. Artese, G. Costa, M. L. Perrore, S. Alcaro and M. Freccero, Org. Biomol. Chem., 2014, 12, 3744
    DOI: 10.1039/C4OB00220B

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author