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Issue 20, 2014
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Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

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Abstract

Chalcones are still challenge substrates in Michael reactions, and only limited success has been achieved. This work describes a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.

Graphical abstract: Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

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Publication details

The article was received on 26 Jan 2014, accepted on 20 Feb 2014 and first published on 21 Feb 2014


Article type: Communication
DOI: 10.1039/C4OB00203B
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 3163-3166
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    Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

    Y. Liu, X. Wang, X. Wang and W. He, Org. Biomol. Chem., 2014, 12, 3163
    DOI: 10.1039/C4OB00203B

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