Issue 22, 2014

Discrimination of adenine nucleotides and pyrophosphate in water by a zinc complex of an anthracene-based cyclophane

Abstract

Combining metal–anion coordination and π–π stacking interactions, a zinc complex of a novel anthracene-based cyclophane was designed to recognise adenine nucleoside polyphosphates. This complex was found to show selective fluorescence enhancement for ATP, ADP, AMP and PPi in neutral aqueous solution. Among them, ADP induced the largest fluorescence change to the complex, while ATP showed the strongest binding affinity to the complex. This property was used to sense ATP in the presence of excess amounts of other phosphates such as ADP, AMP, PPi and Pi.

Graphical abstract: Discrimination of adenine nucleotides and pyrophosphate in water by a zinc complex of an anthracene-based cyclophane

Supplementary files

Article information

Article type
Paper
Submitted
23 Jan 2014
Accepted
16 Apr 2014
First published
16 Apr 2014

Org. Biomol. Chem., 2014,12, 3701-3706

Author version available

Discrimination of adenine nucleotides and pyrophosphate in water by a zinc complex of an anthracene-based cyclophane

P. Hu, S. Yang and G. Feng, Org. Biomol. Chem., 2014, 12, 3701 DOI: 10.1039/C4OB00184B

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