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Cooperative N-heterocyclic carbene (NHC)–Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

Yu Zhang,a   Yingyan Lu,a   Weifang Tang,a   Tao Lu*a and   Ding Du*a  
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State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: lut163@163.com, ddmn9999@cpu.edu.cn
Org. Biomol. Chem., 2014,12, 3009-3015

DOI: 10.1039/C4OB00145A
Received 20 Jan 2014, Accepted 13 Mar 2014
First published online 14 Mar 2014
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