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Issue 18, 2014
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A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish

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Abstract

A strategy based on Pd-mediated ring closure of 1,2-disubstituted indoles containing an unactivated olefin leading to indole-1,2-fused 8- and 9-membered rings has been developed for the identification of new and potential scaffolds for apoptosis. A large number of fused indole derivatives containing an endocyclic double bond were synthesized using this robust methodology. A representative compound showed promising apoptotic properties in zebrafish embryos.

Graphical abstract: A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish

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Publication details

The article was received on 19 Jan 2014, accepted on 20 Feb 2014 and first published on 21 Feb 2014


Article type: Communication
DOI: 10.1039/C4OB00140K
Citation: Org. Biomol. Chem., 2014,12, 2864-2868
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    A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish

    B. Prasad, B. Y. Sreenivas, A. Sushma, S. Yellanki, R. Medisetti, P. Kulkarni and M. Pal, Org. Biomol. Chem., 2014, 12, 2864
    DOI: 10.1039/C4OB00140K

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