Jump to main content
Jump to site search

Issue 15, 2014
Previous Article Next Article

Tandem halogenation/Michael-initiated ring-closing reaction of α,β-unsaturated nitriles and activated methylene compounds: one-pot diastereoselective synthesis of functionalized cyclopropanes

Author affiliations

Abstract

An efficient one-pot synthetic route to highly substituted cyclopropanes has been developed from readily available α,β-unsaturated nitriles and doubly activated methylene compounds under very mild conditions in a highly diastereoselective manner, which involves halogenation, Michael addition and intramolecular ring-closing reaction sequences.

Graphical abstract: Tandem halogenation/Michael-initiated ring-closing reaction of α,β-unsaturated nitriles and activated methylene compounds: one-pot diastereoselective synthesis of functionalized cyclopropanes

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jan 2014, accepted on 18 Feb 2014 and first published on 18 Feb 2014


Article type: Paper
DOI: 10.1039/C4OB00087K
Citation: Org. Biomol. Chem., 2014,12, 2427-2435
  •   Request permissions

    Tandem halogenation/Michael-initiated ring-closing reaction of α,β-unsaturated nitriles and activated methylene compounds: one-pot diastereoselective synthesis of functionalized cyclopropanes

    X. Xin, Q. Zhang, Y. Liang, R. Zhang and D. Dong, Org. Biomol. Chem., 2014, 12, 2427
    DOI: 10.1039/C4OB00087K

Search articles by author

Spotlight

Advertisements