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Issue 26, 2014
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RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

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Abstract

Here we report an efficient method for the synthesis of RNA–peptide conjugates by inverse-electron demand Diels–Alder reaction. Various dienophiles were enzymatically incorporated into RNA and reacted with a chemically synthesized diene-modified peptide. The Diels–Alder reaction proceeds with near-quantitative yields in aqueous solution with stoichiometric amounts of reactants, even at low micromolar concentrations.

Graphical abstract: RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

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Publication details

The article was received on 09 Jan 2014, accepted on 20 May 2014 and first published on 20 May 2014


Article type: Paper
DOI: 10.1039/C4OB00076E
Citation: Org. Biomol. Chem., 2014,12, 4701-4707
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    RNA–peptide conjugate synthesis by inverse-electron demand Diels–Alder reaction

    S. Ameta, J. Becker and A. Jäschke, Org. Biomol. Chem., 2014, 12, 4701
    DOI: 10.1039/C4OB00076E

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