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Issue 19, 2014
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Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

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Abstract

Here, we describe the synthesis of the genetically predicted biosynthetic intermediates of the neurotoxin saxitoxin (STX) (1), 2, 6 and 7, and identification of 2 and 6 in toxin-producing microorganisms. This is the first chemical evidence supporting the genetically predicted biosynthetic route toward 1.

Graphical abstract: Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

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Publication details

The article was received on 09 Jan 2014, accepted on 13 Mar 2014 and first published on 13 Mar 2014


Article type: Communication
DOI: 10.1039/C4OB00071D
Citation: Org. Biomol. Chem., 2014,12, 3016-3020
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    Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

    S. Tsuchiya, Y. Cho, K. Konoki, K. Nagasawa, Y. Oshima and M. Yotsu-Yamashita, Org. Biomol. Chem., 2014, 12, 3016
    DOI: 10.1039/C4OB00071D

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