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Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-κB

Yong Ling,ab   Zhiqiang Wang,ab   Xuemin Wang,a   Ying Zhao,a   Wei Zhang,a   Xinyang Wang,a   Li Chen,bc   Zhangjian Huang*bc and   Yihua Zhang*bc  
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School of Pharmacy, Nantong University, Nantong, PR China
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China
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Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China
Org. Biomol. Chem., 2014,12, 4517-4530

DOI: 10.1039/C4OB00023D
Received 04 Jan 2014, Accepted 24 Apr 2014
First published online 25 Apr 2014
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