Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 18, 2014
Previous Article Next Article

KOAc-promoted alkynylation of α-C–H bonds of ethers with alkynyl bromides under transition-metal-free conditions

Author affiliations

Abstract

A novel KOAc-promoted α-position C–H activation and alkynylation of ethers with alkynyl bromides to 2-alkynyl ethers has been developed under transition-metal-free and simple reaction conditions. In addition, this methodology can also be extended to the vinylation of ethers with vinyl bromides in excellent regio- and stereo-selectivity. A wide range of direct C(sp)–C(sp3) and C(sp2)–C(sp3) bonds has been formed through this protocol, which offers a new and alternative route.

Graphical abstract: KOAc-promoted alkynylation of α-C–H bonds of ethers with alkynyl bromides under transition-metal-free conditions

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 Jan 2014, accepted on 05 Mar 2014 and first published on 06 Mar 2014


Article type: Paper
DOI: 10.1039/C4OB00002A
Citation: Org. Biomol. Chem., 2014,12, 2969-2978
  •   Request permissions

    KOAc-promoted alkynylation of α-C–H bonds of ethers with alkynyl bromides under transition-metal-free conditions

    J. Zhang, P. Li and L. Wang, Org. Biomol. Chem., 2014, 12, 2969
    DOI: 10.1039/C4OB00002A

Search articles by author