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Issue 23, 2014
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Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging

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Abstract

Far-red and near infrared (NIR) emissive dyes have advantages in the development of fluorescent probes and labelling for bio-imaging in living systems since fluorescence in the long-wavelength region would generate minimum photo-toxicity to biological components, deep tissue penetration and minimal background from auto-fluorescence by bio-molecules. BODIPY dyes are attractive due to their excellent photo-physical properties and potential for fluorescence-based sensing and bio-imaging applications. Thus, numerous research papers have emerged to develop BODIPY-based dyes with absorption and emission in the long-wavelength spectral region (650–900 nm). This review summarizes the general strategies to obtain far-red and NIR BODIPYs. Moreover, their applications for fluorescent pH probes and imaging or labelling in living systems are highlighted.

Graphical abstract: Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging

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Publication details

The article was received on 21 Dec 2013, accepted on 01 Apr 2014 and first published on 02 Apr 2014


Article type: Review Article
DOI: 10.1039/C3OB42554A
Citation: Org. Biomol. Chem., 2014,12, 3774-3791
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    Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging

    Y. Ni and J. Wu, Org. Biomol. Chem., 2014, 12, 3774
    DOI: 10.1039/C3OB42554A

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