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Issue 18, 2014
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Gold-catalysed cyclisation of N-propargylic β-enaminones to form 3-methylene-1-pyrroline derivatives

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Abstract

A gold(I) catalysed reaction between N-propargylic β-enaminones and arynes was developed to access 3-methylene-1-pyrrolines. The title compounds were obtained in 57–78% yields. This reaction is useful for the generation of substituted 1-pyrrolines exhibiting significant molecular complexity.

Graphical abstract: Gold-catalysed cyclisation of N-propargylic β-enaminones to form 3-methylene-1-pyrroline derivatives

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Publication details

The article was received on 16 Dec 2013, accepted on 13 Feb 2014 and first published on 13 Feb 2014


Article type: Communication
DOI: 10.1039/C3OB42513D
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 2869-2873
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    Gold-catalysed cyclisation of N-propargylic β-enaminones to form 3-methylene-1-pyrroline derivatives

    K. Goutham, N. S. V. M. R. Mangina, S. Suresh, P. Raghavaiah and G. V. Karunakar, Org. Biomol. Chem., 2014, 12, 2869
    DOI: 10.1039/C3OB42513D

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