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Issue 14, 2014
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Enzyme-promoted regioselective coupling oligomerization of isorhapontigenin towards the first synthesis of (±)-gnetulin

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Abstract

We report the first synthesis of a natural (±)-gnetulin and an unnatural analogue of (±)-gnemonol M by using the regioselective oxidative coupling reactions of 5-tert-butyl-isorhapontigenin as the key step. Both the effects of different enzyme-catalyzed systems on the structures of coupling products and structural transformations of coupling products in the presence of several Lewis acids were systematically investigated.

Graphical abstract: Enzyme-promoted regioselective coupling oligomerization of isorhapontigenin towards the first synthesis of (±)-gnetulin

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Publication details

The article was received on 10 Dec 2013, accepted on 03 Feb 2014, published on 03 Feb 2014 and first published online on 03 Feb 2014


Article type: Paper
DOI: 10.1039/C3OB42456A
Citation: Org. Biomol. Chem., 2014,12, 2273-2279
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    Enzyme-promoted regioselective coupling oligomerization of isorhapontigenin towards the first synthesis of (±)-gnetulin

    W. Li, S. Yang, T. Lv and Y. Yang, Org. Biomol. Chem., 2014, 12, 2273
    DOI: 10.1039/C3OB42456A

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