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Issue 12, 2014
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Disodium cromoglycate: exploiting its properties as a NMR weak-aligning medium for small organic molecules

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Abstract

Chromonic phases are a family of lyotropic liquid crystals (LC) formed by ionic aromatic mesogens such as disodium cromoglycate (cromolyn), sunset yellow and others. It is well known that chromonic phases are oriented in the presence of external magnetic fields, leading to the observation of anisotropic NMR observables such as quadrupolar splittings or residual dipolar couplings. Despite the fact that the cromolyn nematic LC phase (N) presents important advantages like great homogeneity, small line broadening, and easy sample preparation, it has been scarcely used as a water-compatible NMR orienting medium, in part due to a too strong induced degree of alignment on the guest molecules. However, the use of cromolyn–brine mixtures led to the optimum degree of alignment allowing to record 1H–13C dipolar couplings with good accuracy.

Graphical abstract: Disodium cromoglycate: exploiting its properties as a NMR weak-aligning medium for small organic molecules

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Publication details

The article was received on 22 Nov 2013, accepted on 02 Jan 2014 and first published on 07 Jan 2014


Article type: Paper
DOI: 10.1039/C3OB42338G
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 1957-1965
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    Disodium cromoglycate: exploiting its properties as a NMR weak-aligning medium for small organic molecules

    E. Troche-Pesqueira, M. Cid and A. Navarro-Vázquez, Org. Biomol. Chem., 2014, 12, 1957
    DOI: 10.1039/C3OB42338G

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