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Issue 13, 2014
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Fluorescent probes for detecting monoamine oxidase activity and cell imaging

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Abstract

A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL−1 respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells.

Graphical abstract: Fluorescent probes for detecting monoamine oxidase activity and cell imaging

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Publication details

The article was received on 21 Nov 2013, accepted on 25 Jan 2014 and first published on 28 Jan 2014


Article type: Communication
DOI: 10.1039/C3OB42326C
Citation: Org. Biomol. Chem., 2014,12, 2033-2036
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    Fluorescent probes for detecting monoamine oxidase activity and cell imaging

    X. Li, H. Zhang, Y. Xie, Y. Hu, H. Sun and Q. Zhu, Org. Biomol. Chem., 2014, 12, 2033
    DOI: 10.1039/C3OB42326C

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