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Issue 7, 2014
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Rhodium-catalyzed three-component reaction of 3-diazooxindoles with indoles and isatin-derived ketimines: a facile and versatile approach to functionalized 3,3′,3′′-trisindoles

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Abstract

A simple, facile and efficient Rh2(OAc)4-catalyzed three-component reaction of 3-diazooxindoles with indoles and isatin-derived N-Boc ketimines towards a variety of functionalized 3,3′,3′′-trisindoles in high yields with moderate to excellent diastereoselectivities has been developed. This methodology provides an ideal approach for the direct introduction of indole and oxindole into an isatin moiety at the 3-position.

Graphical abstract: Rhodium-catalyzed three-component reaction of 3-diazooxindoles with indoles and isatin-derived ketimines: a facile and versatile approach to functionalized 3,3′,3′′-trisindoles

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Publication details

The article was received on 16 Nov 2013, accepted on 09 Dec 2013 and first published on 10 Dec 2013


Article type: Paper
DOI: 10.1039/C3OB42283F
Citation: Org. Biomol. Chem., 2014,12, 1149-1156
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    Rhodium-catalyzed three-component reaction of 3-diazooxindoles with indoles and isatin-derived ketimines: a facile and versatile approach to functionalized 3,3′,3′′-trisindoles

    L. Mei, X. Tang and M. Shi, Org. Biomol. Chem., 2014, 12, 1149
    DOI: 10.1039/C3OB42283F

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