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Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

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a
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: jiangb@mail.sioc.ac.cn, zhangchen@mail.sioc.ac.cn;
Fax: (+86) 021-6416-6128 ;
Tel: (+86) 021-54925566
b
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
E-mail: lijy@nic.bmi.ac.cn ;
Tel: (+86) 010-6694-8672
c
Shanghai Advanced Research Institute, Chinese Academy of Sciences, 99 Haike Road, Shanghai 201210, China
Org. Biomol. Chem., 2014,12, 3446-3458

DOI: 10.1039/C3OB42186D
Received 05 Nov 2013, Accepted 24 Mar 2014
First published online 25 Mar 2014
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