Issue 12, 2014
From the journal:

Organic & Biomolecular Chemistry

Asymmetric α-amination reaction of alkenyl trifluoroacetates catalyzed by a chiral phosphine–silver complex†

Akira Yanagisawa,*a   Ryoji Miyakea  and  Kazuhiro Yoshidaa  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Chiba University, Inage, Chiba 263-8522, Japan
E-mail: ayanagi@faculty.chiba-u.jp
Fax: +81-(0)43-290-2789
Tel: +81-(0)43-290-2789

Abstract

The asymmetric α-amination of alkenyl trifluoroacetates with dialkyl azodicarboxylates catalyzed by the DTBM-SEGPHOS·AgOTf complex takes place in the presence of 2,2,2-trifluoroethanol with almost quantitative yield and high ees of up to 97%.

Graphical abstract: Asymmetric α-amination reaction of alkenyl trifluoroacetates catalyzed by a chiral phosphine–silver complex

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Article information

DOI
https://doi.org/10.1039/C3OB42111B
Article type
Paper
Submitted
23 Oct 2013
Accepted
21 Jan 2014
First published
22 Jan 2014

Org. Biomol. Chem., 2014,12, 1935-1941

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Asymmetric α-amination reaction of alkenyl trifluoroacetates catalyzed by a chiral phosphine–silver complex

A. Yanagisawa, R. Miyake and K. Yoshida, Org. Biomol. Chem., 2014, 12, 1935 DOI: 10.1039/C3OB42111B

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