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Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase

Bo Jiang,ab   Xiaojing Huang,a   Hequan Yao,a   Jieyun Jiang,c   Xiaoming Wu,*a   Siyi Jiang,d   Qiujuan Wang,d   Tao Lue and   Jinyi Xu*a  
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a
State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: xmwu@cpu.edu.cn, jinyixu@china.com;
Fax: +86-25-83242366 ;
Tel: +86-25-83242366
b
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P. R. China
c
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, USA
d
Department of Physiology, China Pharmaceutical University, Nanjing 210009, P. R. China
e
Laboratory of Molecular Design and Drug Discovery, China Pharmaceutical University, Nanjing 211198, P. R. China
Org. Biomol. Chem., 2014,12, 2114-2127

DOI: 10.1039/C3OB41936C
Received 24 Sep 2013, Accepted 13 Jan 2014
First published online 14 Jan 2014
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