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Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase

Bo Jiang,ab   Xiaojing Huang,a   Hequan Yao,a   Jieyun Jiang,c   Xiaoming Wu,*a   Siyi Jiang,d   Qiujuan Wang,d   Tao Lue and   Jinyi Xu*a  
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State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China
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Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P. R. China
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, USA
Department of Physiology, China Pharmaceutical University, Nanjing 210009, P. R. China
Laboratory of Molecular Design and Drug Discovery, China Pharmaceutical University, Nanjing 211198, P. R. China
Org. Biomol. Chem., 2014,12, 2114-2127

DOI: 10.1039/C3OB41936C
Received 24 Sep 2013, Accepted 13 Jan 2014
First published online 14 Jan 2014
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