Issue 1, 2014

Chiral amides via copper-catalysed enantioselective conjugate addition

Abstract

A highly enantioselective one pot procedure for the synthesis of β-substituted amides was developed starting from the corresponding α,β-unsaturated esters. This new methodology is based on the copper-catalysed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters and subsequent direct formation of amides by quenching the corresponding enolates with different amines. Various primary and secondary amines bearing alkyl or aryl substituents can be used giving rise to a large variety of β-substituted amides with excellent enantioselectivities.

Graphical abstract: Chiral amides via copper-catalysed enantioselective conjugate addition

Article information

Article type
Communication
Submitted
22 Sep 2013
Accepted
28 Oct 2013
First published
29 Oct 2013

Org. Biomol. Chem., 2014,12, 36-41

Chiral amides via copper-catalysed enantioselective conjugate addition

A. K. Schoonen, M. Á. Fernández-Ibáñez, M. Fañanás-Mastral, J. F. Teichert and B. L. Feringa, Org. Biomol. Chem., 2014, 12, 36 DOI: 10.1039/C3OB41923A

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