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Issue 13, 2014
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A fluorescent offon NBD-probe for F sensing: theoretical validation and experimental studies

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Abstract

The design, synthesis and fluoride sensing ability of a 7-nitro-2,1,3-benzoxadiazole (NBD) based chemodosimeter is reported. Theoretical calculations were used to design a more applicable offon response, by choosing NBD as the accurate fluorophore. Reaction of the NBD-probe with 300 equivalents of tetrabutyl ammonium fluoride (TBAF) exhibited a response time of 80 minutes and the reaction was selective to F and sensing of the ion was marked by a 110-fold enhancement of green fluorescence. The offon fluorescence characteristics of the probe enabled its application in live-cell imaging of intracellular F ions.

Graphical abstract: A fluorescent off–on NBD-probe for F− sensing: theoretical validation and experimental studies

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Publication details

The article was received on 16 Sep 2013, accepted on 29 Jan 2014 and first published on 29 Jan 2014


Article type: Paper
DOI: 10.1039/C3OB41886C
Citation: Org. Biomol. Chem., 2014,12, 2143-2149
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    A fluorescent offon NBD-probe for F sensing: theoretical validation and experimental studies

    A. Roy, A. Datar, D. Kand, T. Saha and P. Talukdar, Org. Biomol. Chem., 2014, 12, 2143
    DOI: 10.1039/C3OB41886C

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