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Issue 2, 2014
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Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

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Abstract

A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.

Graphical abstract: Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

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Publication details

The article was received on 26 Jul 2013, accepted on 16 Nov 2013 and first published on 19 Nov 2013


Article type: Communication
DOI: 10.1039/C3OB41539B
Citation: Org. Biomol. Chem., 2014,12, 255-260
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    Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

    J. McNulty, R. Vemula, C. Bordón, R. Yolken and L. Jones-Brando, Org. Biomol. Chem., 2014, 12, 255
    DOI: 10.1039/C3OB41539B

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