Jump to main content
Jump to site search

Issue 3, 2014
Previous Article Next Article

The role of protein characteristics in the formation and fluorescence of Au nanoclusters

Author affiliations

Abstract

Protein-encapsulated gold nanoclusters have shown many advantages over other gold nanocluster systems, including green synthesis, biocompatibility, high water solubility, and the ease of further conjugation. In this article, we systematically investigated the effects of the protein size and amino acid content on the formation and fluorescent properties of gold nanoclusters using four model proteins (bovine serum albumin, lysozyme, trypsin, and pepsin). We discovered that the balance of amine and tyrosine/tryptophan containing residues was critical for the nanocluster formation. Protein templates with low cysteine contents caused blue shifts in the fluorescent emissions and difference in fluorescent lifetimes of the gold nanoclusters. Furthermore, the protein size was found to be a critical factor for the photostability and long-term stability of gold nanoclusters. The size of the protein also affected the Au nanocluster behaviour after immobilization.

Graphical abstract: The role of protein characteristics in the formation and fluorescence of Au nanoclusters

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Nov 2013, accepted on 27 Nov 2013 and first published on 29 Nov 2013


Article type: Paper
DOI: 10.1039/C3NR06040C
Author version
available:
Download author version (PDF)
Citation: Nanoscale, 2014,6, 1515-1524
  •   Request permissions

    The role of protein characteristics in the formation and fluorescence of Au nanoclusters

    Y. Xu, J. Sherwood, Y. Qin, D. Crowley, M. Bonizzoni and Y. Bao, Nanoscale, 2014, 6, 1515
    DOI: 10.1039/C3NR06040C

Search articles by author

Spotlight

Advertisements