Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 5, 2014
Previous Article Next Article

Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Author affiliations

Abstract

Hydrogen peroxide (H2O2) is a “green chemical” that has various cleaning and disinfectant uses, including as an anti-bacterial agent for hygienic and medical treatments. However, its efficacy is limited against biofilm-producing bacteria, because of poor penetration into the protective, organic matrix. Here we show new applications for ferromagnetic nanoparticles (Fe3O4, MNPs) with peroxidase-like activity in potentiating the efficacy of H2O2 in biofilm degradation and prevention. Our data show that MNPs enhanced oxidative cleavage of biofilm components (model nucleic acids, proteins, and oligosaccharides) in the presence of H2O2. When challenged with live, biofilm-producing bacteria, the MNP–H2O2 system efficiently broke down the existing biofilm and prevented new biofilms from forming, killing both planktonic bacteria and those within the biofilm. By enhancing oxidative cleavage of various substrates, the MNP–H2O2 system provides a novel strategy for biofilm elimination, and other applications utilizing oxidative breakdown.

Graphical abstract: Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 12 Oct 2013, accepted on 24 Dec 2013 and first published on 03 Jan 2014


Article type: Communication
DOI: 10.1039/C3NR05422E
Citation: Nanoscale, 2014,6, 2588-2593
  •   Request permissions

    Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

    L. Gao, K. M. Giglio, J. L. Nelson, H. Sondermann and A. J. Travis, Nanoscale, 2014, 6, 2588
    DOI: 10.1039/C3NR05422E

Search articles by author